Remodeling of an injectable, settable, and cell-degradable composite bone cement with bone-like strength in a rabbit femoral plug defect model

Injectable Degradable Composite Materials for Bone Repair and Drug Delivery

Allogenic Bone Graft Enriched by Periosteal Stem Cell and Growth Factors for Osteogenesis in Critical Size Bone Defect in Rabbit Model: Histopathological and Radiological Evaluation

Background & Objective: This study aimed to investigate the effect of decellularized allogeneic bone graft enriched by periosteal stem cells (PSCs) and growth factors on the bone repair process in a rabbit model, which could be used in many orthopedic procedures. Methods: In this experimental study, a critical size defect (CSD) (10 mm) was created in the ...

Injectable Biocomposites for Bone Healing in Rabbit Femoral Condyle Defects

A novel biomimetic bone scaffold was successfully prepared in this study, which was composed of calcium sulfate hemihydrate (CSH), collagen and nano-hydroxyapatite (nHAC). CSH/nHAC was prepared and observed with scanning electron microscope and rhBMP-2 was introduced into CSH/nHAC. The released protein content from the scaffold was detected using high performance liquid chromatography at predet...

Evaluation of Compressive Mechanical Properties of the Radial Bone Defect Treated with Selected Bone Graft Substitute Materials in Rabbit

Objective- To determine the effect of selected bone graft on the compression properties of radialbone in rabbit.Design- Experimental in vivo study.Animals- A total of 45 adult male New Zealand white rabbits.Procedures- The rabbits were anesthetized and a one-cm-full thickness piece of radial bone wasremoved using oscillating saw in the all rabbit. The rabbits were divided into 5 groups on theba...

A novel injectable and degradable calcium phosphate/calcium sulfate bone cement

The aim of this study was to obtain a composite material which not only has suitable workability but also has excellent degradability. A novel injectable and degradable bone cement consisting of a mixture of calcium phosphate (α-tricalcium phosphate; α-TCP) and calcium sulfate dihydrate (CaSO4. 2H2O; CSD) powders as the solid phase and an aqueous solution containing 2.5 weight percent of Na2HPO...